Effects and safety assessment of methylprednisolone on postoperative nausea and vomiting and pain after total knee arthroplasty

doi:10.3969/j.issn.2095-4344.2017.03.002

Abstract

Abstract:

BACKGROUND: At present, dexamethasone has been widely used in the perioperative period of major surgery in the orthopedics for reducing postoperative pain and nausea and vomiting, but the study on the application of methylprednisolone to reducing postoperative nausea and vomiting and pain after unilateral total knee

arthroplasty is rarely reported.

OBJECTIVE: To evaluate the effects and safety assessment of the application of methylprednisolone on postoperative nausea and vomiting and pain after unilateral total knee arthroplasty.

METHODS: A total of 86 patients undergoing unilateral total knee arthroplasty were randomly assigned to two groups. Patients in the methylprednisolone group were given methylprednisolone 40 mg in intravenous drip within 24 hours during and after replacement. Patients in the control group were given an equal volume of saline in intravenous drip at the same time. The incidence of postoperative nausea and vomiting was observed and recorded at 0-6 hours, 6-24 hours, 24-48 hours, and 48-72 hours after surgery, as well as the total incidence was recorded in both groups. Pain visual analogue scale (VAS) score at 6, 24, 48 and 72 hours after replacement, and knee joint scoring system (KSS) score at 3 days after replacement were recorded. C-reactive protein and fasting blood glucose were determined. The occurrence of adverse reactions postoperatively was recorded in 6-month follow-up in both groups.

RESULTS AND CONCLUSION: (1) The total incidence rate of postoperative nausea and vomiting during 0-72 hours after surgery, and incidence rates of nausea and vomiting at 6 and 24 hours were significantly lower in the methylprednisolone group than in the control group (P < 0.05). (2) Pain VAS score was significantly lower in the methylprednisolone group than in the control group at 6 and 24 hours after surgery (P < 0.05). (3) KSS scores were significantly higher in the methylprednisolone group than in the control group after surgery (P < 0.05). (4) C-reactive protein and fasting blood glucose were not significantly different between two groups before and after surgery (P > 0.05). (5) The surgical incision was found to heal in 3-month follow-up and no postoperative infection occurred in both groups. (6) Results show that methylprednisolone can obviously reduce postoperative nausea and vomiting and pain in unilateral total knee arthroplasty, and did not increase the incidence of postoperative infection.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Arthroplasty, Replacement, Methylprednisolone, Nausea, Vomiting, Pain, Tissue Engineering

CLC Number:

R318

Tian Hai-tao, Wang Yuan-he, Tian Shao-qi, Zhang Xu-teng, Sun Kang. Effects and safety assessment of methylprednisolone on postoperative nausea and vomiting and pain after total knee arthroplasty[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(3): 335-339.

Figures/Tables 1

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